2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine - Names and Identifiers
Name | Fmoc-2,4-Dichloro-D-phenylalanine
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Synonyms | FMOC-2 FMOC-D-2 -3-(2,4-dichlorophenyl) -2-((((9H-Fluoren-9-yl) Fmoc-D-2,4-Dichlorophenylalanine Fmoc-2,4-Dichloro-D-phenylalanine (R)-Fmoc-2-amino-3-(2,4-dichlorophenyl)propionic acid 2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine 2,4-dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine D-phenylalanine, 2,4-dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]- (R)-2-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-3-(2,4-dichlorophenyl)propanoic acid (2R)-3-(2,4-Dichlorophenyl)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanoic acid (2R)-3-(2,4-dichlorophenyl)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoic acid
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CAS | 352351-61-2
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InChI | InChI=1/C24H19Cl2NO4/c25-15-10-9-14(21(26)12-15)11-22(23(28)29)27-24(30)31-13-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-10,12,20,22H,11,13H2,(H,27,30)(H,28,29)/t22-/m1/s1 |
2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine - Physico-chemical Properties
Molecular Formula | C24H19Cl2NO4
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Molar Mass | 456.32 |
Density | 1.394g/cm3 |
Boling Point | 659.9°C at 760 mmHg |
Flash Point | 352.9°C |
Vapor Presure | 2.59E-18mmHg at 25°C |
Storage Condition | 2-8°C |
Refractive Index | 1.641 |
2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin.
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Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36 - Wear suitable protective clothing.
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WGK Germany | 3 |
2,4-Dichloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-phenylalanine - Introduction
Fmoc-2,4-Dichloro-D-phenylalanine is an important amino acid derivative with many properties and applications. The following is a description of the properties, uses, preparation and safety information of Fmoc-2,4-Dichloro-D-phenylalanine:
Nature:
1. Chemical formula: C21H17Cl2NO4
2. molecular weight: 416.27g/mol
3. Appearance: white crystal or powder
4. melting point: 165-167 ℃
5. Solubility: Slightly soluble in organic solvents, such as dimethyl sulfoxide and dichloromethane
Use:
Fmoc-2,4-Dichloro-D-phenylalanine is mainly used as a protecting group in peptide synthesis and solid phase synthesis in chemical synthesis. It can be added to the peptide chain as an amino acid unit with a protecting group, and the protecting group is removed with a base after the reaction to obtain a peptide containing a D-2, 4-dichlorophenylalanine residue.
Preparation Method:
A commonly used method for the synthesis of Fmoc-2, 4-Dichlororo-D-phenylalanine is to attach an Fmoc protecting group to D-2, 4-dichlorophenylalanine. This is typically achieved by reaction with an Fmoc-subunit amino acid and the introduction of a protecting group into the D-2, 4-dichlorophenylalanine molecule under appropriate conditions.
Safety Information:
Fmoc-2,4-Dichloro-D-phenylalanine is usually a relatively safe compound under correct operation. However, we recommend following safety measures when using:
1. avoid direct exposure to the skin, eyes and mucous membranes, so as not to cause irritation.
2. Use appropriate protective equipment during operation, such as lab gloves and safety glasses.
3. Store the compound in a dry, cool, well-ventilated place, and away from combustibles and oxidants.
4. Follow proper laboratory procedures and waste disposal methods.
Please note that this answer is for reference only, and when using or handling Fmoc-2,4-Dichloro-D-phenylalanine, please consult a professional for accurate and reliable information.
Last Update:2024-04-10 22:29:15